The first delivery of the vaccine will be on 26 December with the first vaccinations taking place on 30 December, the health minister has said.
In a tweet, Stephen Donnelly said: "In what's been such a tough year for so many, this is really great to see."
The Republic of Ireland returns to stricter coronavirus restrictions on Christmas Eve until 12 January.
Under the new restrictions, restaurants and gastro pubs must close for indoor dining from Christmas Eve and are only permitted to offer takeaway or delivery services.
Hairdressers, nail bars, cinemas, galleries and museums must also close.
Authorisation of the Pfizer-BioNTech Covid-19 vaccine in the country comes at a time when coronavirus cases are rising significantly.
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