The shrine, which is highly revered by Shia Muslims, has been targeted before, most recently in February last year.
The attacks came as delegates from the Syrian government and opposition groups gathered in Geneva for tentative UN-sponsored peace talks.
The main opposition group backed down from its threat to boycott the talks. but says the Syrian government must meet key demands if negotiations are to start.
The head of the Syrian government delegation at the Geneva talks, Bashar al-Jaafari, said the attack confirmed the link between the opposition and terrorism.
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