It is not known yet whether the strike took place on the Pakistani side or the Afghan side.
Two vehicles were also destroyed in the strike, said the report.
The identities of the killed are not known at this point.
Monday`s U.S. drone strike is the second of its kind since the beginning of this year if it took place on the Pakistani side.
There is a sharp decline in the number of U.S. drone strikes in Pakistan in 2015 and 2016 compared with the previous years.
Pakistan has always opposed to U.S. drone strikes in its territory as such strikes violate its sovereignty and territorial integrity.
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