The bulk of the layoffs is set to come from its commercial aircraft division as customers cut back on orders.
Hundreds of executives and managers are also expected to lose their jobs.
The cuts account for almost 3% of Boeing`s workforce, which comprised 161,000 people at the end of last year.
Boeing is reacting to concern that demand for its jets is slowing.
The US company has also been losing market share to rival Airbus Group SE.
Boeing delivered a record 762 planes last year, exceeding its previous forecast. However, last year saw a big fall in new orders.
Customers in the Middle East and Asia, who had been on a spending spree, have been cutting back.
As of 31 December, Boeing`s backlog of orders stood at 5,795, representing more than seven and a half years of production at the current rate.
With Boeing and Airbus factories running at full capacity, airlines have been reluctant to spend billions of dollars on aircraft that they would not receive for several years.
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