Leornard Kimaiyo, the police chief in the Kambu area of Maukeni county, says the bus was heading to Mombasa and the trailer in the opposite direction when they collided on Tuesday.
Road accidents kill around 3,000 people in Kenya every year.
Deaths through road accidents have increased in recent years despite a crackdown on drunk driving, including tougher fines and breathalyzer tests at random police roadblocks.
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