"There are at least six civilians dead and the number is expected to rise," said Mohammad Adnan, a rebel official from Jaish Ahrar al-Ashair who runs the policing of the camp.
Islamic State said in a statement on its Amaq news agency its fighters "carried out the Rukban camp attack", according to the U.S.-based SITE monitoring group. It gave no further details.
In January, a car bomb killed a number of people in the camp, and Islamic State militants have since launched attacks on Syrian rebels in the area.
Rukban, near the joint Syria-Iraq-Jordan border, is home to refugees and also to rebel groups, including the Jaish Ahrar al-Ashair, which fight both President Bashar al-Assad and the Islamic State movement. It was also hit by bomb attacks last year.
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