At least 10 people were killed in the city and police say most of the shootings were gang related.
"We will not be defeated," police chief Fred Waller told reporters on Sunday.
"We need more help from our judicial system. We need more help from our federal partners, and we are getting it," he added.
Most of the shootings happened on Sunday with 30 people shot between midnight and 03:00.
The majority of the incidents reportedly occurred in Chicago's south and west sides.
"It's one of our most violent weekends, there's no question about that," a police spokesman told a news conference on Sunday.
Donovan Price, a pastor and emergency administrator, told CBS News that the city was like a "war zone".
"This is just out of control right now," he said. "It's a war zone going on right now. Chicago is just crazy."
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